Posted by Maxime on March 21, 2005, at 14:24:26
In reply to Parnate augment, posted by willyee on March 21, 2005, at 6:58:36
How much amitriptyline should be used to augment the Parnate?
Maxime
> OOPS sorry this should have posted before the one after with the link,see what happens when u try to have messagner open with people doing that annoying BUZZ and scaring the hell out of me,here is my post....
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> I once had the tca amitriptyline from a friend who dident use them.I hadent plan on using them,but she told they put her to sleep,so i took it just in case.
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> Well in one of my many parnate times when it seemed it was totaly ineffective,i took the amitriptyline during the day.I remeber having a great ant-idepressant response,but had no more pills to be sure,plus i wasnt thinking that might have been why.
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> I remembered what i took,and now am waiting on a order of amitriptyline any day now.I want to be careful,and i think its funny that i came across this information regarding the two.......
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> "This is an approximate order of potency. Iproniazid is seldom used now because of the increased risk of hepatotoxicity. Tranylcypromine is the most likely to cause a 'cheese reaction and isocarboxazid the least. An important paper in The lancet, from St. Bartholomew's Hospital, (Pare et al., l982) described the safety and efficacy of combining amitriptyline (Tryptizol) and tranylcypromine (Parnate) - If the patient was on tranylcypromine alone, the rise in blood pressure produced by tyramine1 the dangerous ingredient in cheese, was substantial. The rise in blood pressure was less following a tyramine injection when the patient was on amitriptyline and tranylcypromine. The safety and efficacy of this combination was demonstrated in a controlled trial from the University of Southern California (Raaani et al, 1983) - The other antidepressants investigated at Barts in combination with tranylcypromine were trimipramine (Surmontil) and dothiepin (Prothiaden). They did not confer the same degree of protective effect as amitriptyline.
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> In summary, it is safer to use tranylcypromine combined with amitriptyline than tranylcypromine alone. Even on this combination however, dietary restriction and an MAOI card are essential. Certain MAOI + tricyclic combinations eg. with clomipramine (Anafranil) or imipramine (Tofranil) are potentially lethal and should never be used. The use of combined antidepressants is complicated and should be restricted to those who are familiar with it."
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> I can attest for imipramine,they went horrable when the too were even close in my system by date,so on two factors this article is right in my account.So im curious if anyone had any experieance on using these two specific meds togther,but only these not a third such as a mood stablizer,if so id love to hear ur response.
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> I think parnate is very very suspectable to any addition of another drug,more so than ur common meds,so adding a ani anxiety med or stablizer affects parnate efficancy to a much higher and significant degree than simply adding it to the newer genration ones.
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poster:Maxime
thread:473479
URL: http://www.dr-bob.org/babble/20050317/msgs/473648.html