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Re: Can Procyclidine make you euphoric?

Posted by Iansf on March 17, 2005, at 21:29:54

In reply to Can Procyclidine make you euphoric?, posted by pretty_paints on March 14, 2005, at 7:14:11

From a web seminar on anitcholinergic psychosis:

The first report of abuse of an anticholinergic was reported in 1960 (Hidalgo and Mowers 1990, Land et al 1991). Over 100 cases have been reported in the literature of excessive use of benztropine, trihexyphenidyl, or procyclidine. Case reports and small studies indicate that patients experience a buzz (e.g., euphoria) and/or are more relaxed, energetic, and sociable while ingesting these compounds. Patients noted to abuse anticholinergics are more likely to have a history of polysubstance abuse and an Axis II diagnosis of antisocial personality disorder (Hidalgo and Mowers 1990). Though one report indicates that trihexyphenidyl might have a higher abuse than other anticholinergics (Hidalgo and Mowers 1990), this conclusion was not shared by other authors (Land et al 1991). Tolerance to the euphorigenic effects can occur as trihexyphenidyl doses from 15 to 2000 mg/d of have been reported (Hidalgo and Mowers 1990). It is important to note that some patients with schizophrenia increase the dose of their anticholinergic to reduce their extrapyramidal side effects (Hidalgo and Mowers 1990). If a patient with an extrapyramidal side effect is abusing anticholinergics, then an alternative treatment such as beta-blockers or amantadine might be considered (see Treatment of Extrapyramidal Side Effects handout).


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