Posted by Sarah T. on March 13, 2005, at 1:22:57
Have any of you ever had the feeling that your medication might not be dissolving properly, and that if it had better solubility, maybe it would work better? On more than several occasions, I've the unpleasant experience (sorry about this, it's kind of graphic and disgusting) of seeing some medicines in the toilet bowl, if you know what I mean. In other words, after I swallowed them, they never dissolved, but just passed through, whole, even though I drank a full glass of water with the drug. Another possible problem with solubility occurred a few years ago, when I tried Adderall. When I took one 10 mg tablet of Adderall, it seemed to work better than two 5 mg tablets of Adderall. In fact, the two 5mg tablets seemed to have no effect at all. This makes no sense. First, I looked them up and found that both the five and ten mg tablets were made of the exact same ingredients at that time (I don't know whether that is still the case; it's possible that the filler ingredients might have changed in the past few years). Secondly, I would think that the two 5 mg tablets would have better solubility than one 10 mg tablet because of the increased surface area of the two fives. Has anyone here had a similar experience? I thought I remembered reading somewhere that the salts that comprise Adderall have rather poor solubility, but that still doesn't explain why the two 5's had no effect on me at all, and the one 10 mg tablet packed quite a punch. Other than swallowing our medicines with a full glass of water, how can we be certain that our medicines are dissolving well? Should we drink them with warm or hot water? Is it better to get rx's for the liquid form if liquid is available? Thanks for any ideas.
poster:Sarah T.
thread:470325
URL: http://www.dr-bob.org/babble/20050312/msgs/470325.html