Posted by Optimist on February 27, 2005, at 11:40:49
In reply to Re: Parnate » Optimist, posted by ed_uk on February 26, 2005, at 10:40:28
> Where have you read this? I honestly wouldn't recommend increasing the dose until you've been on 60mg long enough to find out how it's going to affect you.
I can't remember the exact sources... mostly from doing searches here and on google. I think Jay Amsterdam MD, says something about it specifically. He supposedly routinely uses high dose Parnate(up to 330mg) with TRD patients. I know Chairman_MAO mentioned the high dose change in pharmacodynamics a couple times here.
The lithium isn't so much to increase the effectiveness of Parnate as it is to prevent poopout... more as a prophylactic. My grandmother was Bipolar 1, and had a tragic ending after she went off her lithium 30 years ago. My sister may most possibly be bipolar 1 as well. She hasn't been diagnosed as so... so far she's been diagnosed with some schizoaffective disorder. When she's psychotic though she hardly sleeps at all, and has felt suicidal at other times. She's currently taking 60mg Celexa, and 15mg Zyprexa. Lastly my father has had major depression for the last 20 years. He's hinted at having hypomania at times, but the depression is there probably 99% of the time. He's on Amitryptaline, and Divalproex(Epival), partly for depression and partly for chronic migraine prophylaxis.
I've wrestled with the idea that I may have some bipolar variant for a number of years now, probably cyclothymia or a form that goes from dysthymia to normal. I've been called a Dr. Jeckle and Mr. Hyde by my current girlfriend. :)
> >If I was in your case I think I would just order the stuff my self.
>
> I'm thinking of it!Whatever you do make sure you have the necessary failsafes to keep you on track. Arming yourself with a lot of knowledge can only make things better. You seem well on your way to achieving that though. :)
Brian
poster:Optimist
thread:460810
URL: http://www.dr-bob.org/babble/20050227/msgs/464047.html