Posted by ed_uk on February 15, 2005, at 8:44:43
In reply to Re: My Formula for MD, ANX, ADHD.?, posted by banga on February 15, 2005, at 7:55:52
Hi,
>Well Luvox, Prozac, and Paxil are the most potent enzyme inhibitors.
They inhibit different enzymes though. Luvox (fluvoxamine) can significantly raise the plasma concentration of some TCAs but desipramine is generally little affected.
Effect of fluvoxamine on the pharmacokinetics of imipramine and desipramine in healthy subjects.Spina E, Pollicino AM, Avenoso A, Campo GM, Perucca E, Caputi AP.
Institute of Pharmacology, University of Messina, Italy.
The effect of the selective serotonin reuptake inhibitor fluvoxamine (100 mg/day for 10 consecutive days) on the kinetics of a single oral dose of imipramine (50 mg) and desipramine (100 mg) was investigated in 12 healthy subjects. Compared with a control session, treatment with fluvoxamine caused a significant prolongation of imipramine half-life (from 22.8 +/- 6.4 to 40.5 +/- 5.0 h, means +/- SD, p < 0.01) and a marked decrease in imipramine apparent oral clearance (from 1.02 +/- 0.19 to 0.28 +/- 0.06 L/h/kg, p < 0.0001). No significant changes in desipramine kinetics were observed during fluvoxamine treatment. These findings indicate that, at the dosage tested, fluvoxamine markedly inhibits the demethylation of imipramine without affecting significantly the CYP2D6-mediated hydroxylation of desipramine.
Fluvoxamine-induced alterations in plasma concentrations of imipramine and desipramine in depressed patients.
Spina E, Pollicino AM, Avenoso A, Campo GM, Caputi AP.
Institute of Pharmacology, University of Messina, Italy.
The effect of fluvoxamine maleate, 100 mg/day for 10 days, on plasma concentrations of tricyclic antidepressants was studied in 15 depressed patients on maintenance therapy with imipramine (7 pts.) or desipramine (8 pts.). In the subgroup treated with imipramine, plasma levels of imipramine increased significantly (p < 0.001) during fluvoxamine coadministration, while levels of desipramine were not modified. Addition of fluvoxamine to patients on a stable desipramine dosage regimen resulted in a slight, but statistically not significant, increase in desipramine plasma concentrations. These results suggest that fluvoxamine is a potent inhibitor of imipramine demethylation, while it has a weak effect on the hydroxylation of desipramine.
poster:ed_uk
thread:457622
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