Posted by TheOutsider on February 13, 2005, at 5:20:27
In reply to Effexor: Marketing Ploy, posted by ed_uk on February 12, 2005, at 20:25:09
> The blockade of serotonin (5-HT) and norepinephrine (NE) transporters in vitro and in vivo by the dual 5-HT/NE reuptake inhibitors duloxetine and venlafaxine was compared. Duloxetine inhibited binding to the human NE and 5-HT transporters with K(i) values of 7.5 and 0.8 nM, respectively, and with a K(i) ratio of 9. Venlafaxine inhibited binding to the human NE and 5-HT transporters with K(i) values of 2480 and 82 nM, respectively, and with a K(i) ratio of 30.
It is interesting that Duloxetine is so skewed towards seratonin.
I suspected that it didn't have a very significant effect on norepinephrine compared to seratonin because so many people experienced apathy on it!Apparently a drug called Milnicpran (hope I got the name right) is a much more balanced re-uptake inhibitor of both norepinephrine and seratonin.
It is available in most of mainland Europe, but not in the US, Canada or UK.
I wonder why not the UK? Dulouxetine was aproved in the UK almost strait away! Sometimes I hate this country!
poster:TheOutsider
thread:456946
URL: http://www.dr-bob.org/babble/20050212/msgs/457076.html