Posted by zeugma on February 4, 2005, at 19:10:33
In reply to Re: ABILIFY may have trashed my LIBIDO » bipolarspectrum, posted by SLS on February 4, 2005, at 16:11:40
The other thing I was thinking is that it might produce a pro-serotonin effect like the SSRIs by acting to stimulate 5-HT1a receptors, but I really haven't thought the whole thing through yet.
hi Scott. And I apologize for 'tossing your name around' before, I was trying to help Maxime and your experience is matchless (which I know is something of a mixed blessing- nonetheless you are truly knowledgeable and reliable as well as experienced). Buspirone stimulates 5-HT1A receptors and yet it can reverse SSRI s/e, and one of the few things positive that anyone generally says about this is that it is one of the few meds that doesn't dampen the libido. Of course, buspirone also metabolizes to an alpha-2 antagonist, so this could be responsible, but at the very least its 5-HT action doesn't block its pro-sexual effect, and may very well enhance it.Have you ever tried seroquel? I think that it and clozapine are the only AP's that don't increase prolactin, which could be behind the sexual side effects. Of course, I've read that buspirone, too, increases PRL, so who knows...
-z
poster:zeugma
thread:452986
URL: http://www.dr-bob.org/babble/20050202/msgs/453393.html