Posted by djmmm on January 31, 2005, at 10:12:23
In reply to Interesting info about Nardil, posted by Maxime on January 30, 2005, at 23:20:25
> I was doing some research on this horrid med Nardil that I am taking ( as oppose to my beloved Parnate which decided to stop working). And it apparently you take Nardil at high dosages (60-90 mg) until your depression is gone and then you lower the dose dramatically to maintain (to about 15 mg a day).
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> Has anyone else heard about this?
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> It would make me feel better to know that I don't have to take this stuff forever.
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> I hate it.
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> MaximeSince Nardil is considered an "irreversible" MAOI-- meaning it formes a permanent covalent bond to MAO enzymes-- MAO activity is consistant until new MAO is manufactured by the mitochondria of your cells.
Parnate is not considered completely irreversible, since new MAO is produced more rapidly, due to the cohesivness of the bond Parnate forms with MAO enzymes.
Nardil is also a hydrazine deravitive. These meds tend to "build up" in your system, often requiring liver function tests (due to potential liver toxicity). Because Nardil is truely "irreversible" and accumulates in your body, taking a "maintenance" dose of as little as 15mg every other day is possible for most people (only after maximum effect is achieved).
Im not too familiar with "poop-out" and MAOIs. My theory is that "poop-out" is mostly a serotonin issue, excess serotonin to be specific.
poster:djmmm
thread:450404
URL: http://www.dr-bob.org/babble/20050128/msgs/450511.html