Posted by yxibow on January 28, 2005, at 14:24:28
In reply to Re: Yxibow » pretty_paints, posted by ed_uk on January 28, 2005, at 13:42:38
> Hi!
>
> >Have I got the wrong end of the stick?
>
> No! Clozaril isn't mild... but it is a low-potency AP. Because it isn't very potent, high doses are necessary. Seroquel is also low-potency, but Clozaril is probably more effective than Seroquel.
>
> Ed.
My reference to mild was both in terms of potency mg for mg, but also in terms of their transmitter profile and more to the point their potential to cause EPS, especially akathisia. From my personal experience and general guessing of other agents, the latter (EPS) there would be (Older agents)->Risperdal->{Geodon, Abilify}->Zyprexa->Seroquel->Clozaril.Sertindole, Amisulpride, and Sulpride somewhere in the middle of it, for those out of the US, I can only guess.
In terms of how much of a grip an agent could put on your system, Clozaril, is correctly not a "mild" agent, it was the first atypical and because it shares an almost completely different transmitter profile it is considered the "gold standard" for hard to treat schizophrenia cases.
poster:yxibow
thread:444643
URL: http://www.dr-bob.org/babble/20050128/msgs/449229.html