Valium+Grapefruit juice=1.5% increase

Posted by paulbwell on January 26, 2005, at 3:13:30

In reply to Benzos and Grapefruit juice, posted by Kon on January 25, 2005, at 12:52:03

> Just curious, has anybody experimented with combining the two to increase the effectiveness of any benzo. Grapefruit seems to increase the bioavailability of a number of benzos (esp Valium) and other drugs by inhibiting some of the enzymes (i.e. CYP3A4) that metabolize these drugs. It seems to have less effect on clonazepam/xanax, however. I've come across papers suggesting a potential therapeutic benefit in using grapefruit to increase drug bioavailibility. Any experiences?
>
>
Yep, I have, it increases cmax by 1.5%
althought delays this til 2 hours
2mgs (white) becomes 3mgs
5mgs (yellow) becomes 7.5mgs
10mgs (blue) becomes 15mgs
You get the picture

Thread

Benzos and Grapefruit juice Kon 1/25/05
Valium+Grapefruit juice=1.5% increase paulbwell 1/26/05
Re: Valium+Grapefruit juice=1.5% increase » paulbwell tensor 1/26/05
Re: Valium+Grapefruit juice=1.5% increase paulbwell 1/26/05
Re: Benzos and Grapefruit juice Minnie-Haha 1/26/05
Re: Benzos and Grapefruit juice gromit 1/29/05

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