Posted by Optimist on January 24, 2005, at 18:58:38
I've been looking at the K values given for different test ligands of specific drugs and am having trouble understanding their meaning.
For example Tranylcypromine(Parnate) had a K value of >10,000(nM) at the Dopamine D2 receptor.
d-amphetamine has a K value of >10,000 as well for the Dopamine D2 receptor.
Bromocriptine has a K value of 2...
Bupropion(Wellbutrin) has a K value of >100,000...
Olanzapine(Zyprexa) has a K value of 31...
So I'm a little confused on what the K value means. Does a higher number mean more dopamine being bound to the post-synaptic D2 receptor, or vice versa? Or is it something totally different?
Also what does the dopamine transporter mean? Is it the amount of dopamine released from the presynaptic terminal?
As well what is the clinical significance of these values? Do they predict any specific treatment response?
Thanks guys,
Brian
poster:Optimist
thread:447007
URL: http://www.dr-bob.org/babble/20050124/msgs/447007.html