Posted by zeugma on January 11, 2005, at 16:34:36
In reply to Provigil - glutamate - benzos, posted by emme on January 11, 2005, at 12:09:11
Here is the article on Provigil's supposed neuroprotection against glutamergic cytotoxicity:
Neuroreport. 1998 Dec 21;9(18):4209-13.
Modafinil prevents glutamate cytotoxicity in cultured cortical neurons.Antonelli T, Ferraro L, Hillion J, Tomasini MC, Rambert FA, Fuxe K.
Department of Experimental and Clinical Medicine, University of Ferrara, Italy.
The ability of modafinil (Modiodal) to protect cortical neurons from glutamate-induced degeneration was evaluated by measuring electrically evoked [3H]GABA release and [3H]GABA uptake in primary cerebral cortical cultures. In normal cells, electrical stimulation (10 Hz, 2 min) increased [3H]GABA release (FR-NER St1 = 0.77+/-0.14; St2/St1 ratio = 0.94+/-0.02). The exposure of sister cells to glutamate, reduced electrically evoked [3H]GABA release (FR-NER St1 = 0.40+/-0.05; St2/St1 ratio = 0.60+/-0.08). Modafinil (0.3-1 microM) prevented the glutamate-induced reduction of the St2/St1 ratio (0.85+/-0.11; 0.88+/-0.05, respectively). A similar protective effect was observed for [3H]GABA uptake. These findings suggest that modafinil may be neuroprotective in that it attenuates glutamate-induced excitotoxicity in cortical neurons.
Since this was all that came up when I typed the words 'modafinil glutamate cytotoxicity' into the search engine, I assume there have been no more recent studies that contravene this suggestion.Hopefully, minds more trained than mine can look at this and see if it means what it seems to mean.
-z
poster:zeugma
thread:440648
URL: http://www.dr-bob.org/babble/20050108/msgs/440741.html