Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

the wonders of PubMed » emme

Posted by zeugma on January 11, 2005, at 16:34:36

In reply to Provigil - glutamate - benzos, posted by emme on January 11, 2005, at 12:09:11

Here is the article on Provigil's supposed neuroprotection against glutamergic cytotoxicity:

Neuroreport. 1998 Dec 21;9(18):4209-13.

Modafinil prevents glutamate cytotoxicity in cultured cortical neurons.

Antonelli T, Ferraro L, Hillion J, Tomasini MC, Rambert FA, Fuxe K.

Department of Experimental and Clinical Medicine, University of Ferrara, Italy.

The ability of modafinil (Modiodal) to protect cortical neurons from glutamate-induced degeneration was evaluated by measuring electrically evoked [3H]GABA release and [3H]GABA uptake in primary cerebral cortical cultures. In normal cells, electrical stimulation (10 Hz, 2 min) increased [3H]GABA release (FR-NER St1 = 0.77+/-0.14; St2/St1 ratio = 0.94+/-0.02). The exposure of sister cells to glutamate, reduced electrically evoked [3H]GABA release (FR-NER St1 = 0.40+/-0.05; St2/St1 ratio = 0.60+/-0.08). Modafinil (0.3-1 microM) prevented the glutamate-induced reduction of the St2/St1 ratio (0.85+/-0.11; 0.88+/-0.05, respectively). A similar protective effect was observed for [3H]GABA uptake. These findings suggest that modafinil may be neuroprotective in that it attenuates glutamate-induced excitotoxicity in cortical neurons.


Since this was all that came up when I typed the words 'modafinil glutamate cytotoxicity' into the search engine, I assume there have been no more recent studies that contravene this suggestion.

Hopefully, minds more trained than mine can look at this and see if it means what it seems to mean.

-z


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:zeugma thread:440648
URL: http://www.dr-bob.org/babble/20050108/msgs/440741.html