Posted by don_bristol on January 10, 2005, at 14:38:37
Does anyone know of the interaction between the anti-fungal medication Lamisil (terbinafine) and Parnate?
I have been taking 40 mg Parnate for a few months. Recently I had to take 250 mg of oral Lamisil for 6 weeks.
Maybe it was just a co-incidence but soon after I started taking the Lamisil I felt the Parnate was much "stronger" than usual. I was more wakeful and had trouble wanting to go to sleep as I was not feeling sleepy at nights. I would estimate that the effect was equivalent to something like an extra 10 to 15 mg Parnate.
(Also my regular sleeping medication 10mg Zolpidem i.e. Ambien seemed to be much more potent when I was on Lamisil. This time it seemed to double in strength.)
I am not sure it was merely co-incidence. But there is little info on Lamisil interactions with MAOIs. The most explicit I have found is this from http://www.healthdigest.org/TERBINAFINE-(Oral)-(Tablet)_6749_PRO.php
"Make sure your doctor knows if you are also using cimetidine .... , blood pressure medicine .... , an MAO inhibitor (Eldepryl, Marplan, Nardil, Parnate), or medicine for depression (amitriptyline, clomipramine, ....".
Can anyone who understands the chemistry say if the P450 enyzme system explains why Lamisil *seemed* to block the breakdown of Parnate?
It is said that Lamisil is a potent inhibitor of CYP2D6. I don't really understand this topic but I have read that Parnate is a potent inhibitor of CYP2A6 as well as having something to do with several other enzymes in the P450 system.
Does anyone have any further info on this topic?
Thank you for any information.
Don.
poster:don_bristol
thread:440184
URL: http://www.dr-bob.org/babble/20050108/msgs/440184.html