Posted by Larry Hoover on December 31, 2004, at 22:39:25
In reply to Low-dose selegiline and anxiety » Larry Hoover, posted by cache-monkey on December 31, 2004, at 10:38:10
> > Low-dose selegiline (or the new transdermal delivery system) are yet other options.
>
> I've actually been thinking about low-dose selegiline, as the dopamine would benefit a cluster of my symptoms that I most want to deal with: social anxiety, smoking, concentration/ADD-like issues. I've also heard it's libido-enhancing, which is a big plus.
>
> BUT, my depressions/dysthymias are usually coupled with pretty bad anxiety. (I might have a soft BP or cyclothymia because I also -- at least in the past -- have had up periods that can be characterized by a nervous, ill-focused type of energy.) So, while I think selegiline would be very beneficial in a number of ways, I'm concerned that it might exacerbate my generalized anxiety due to down-regulation of 5-HT, given the reciprocal relationship between 5-HT and DA systems.
>
> Any thoughts?
> cache-monkeyIt's fine to do thought experiments, but I've heard of so many paradoxical reactions and such like that, in the end, it comes down to a drug trial. There are various ways to manipulate the anxiogenic and anxiolytic effects of meds, if you go at it systematically. That's a large part of what we talk about on the Alternative board; augmentative strategies, synergies, treatment of side effects.
Lar
poster:Larry Hoover
thread:435794
URL: http://www.dr-bob.org/babble/20041228/msgs/436203.html