Posted by rod on December 25, 2004, at 18:53:07
Hi!
Some weeks have passed since I announced I will begin my Lyrica trial. So far, I am having a positive experience with Lyrica, but limited due to my poly drug treatment.
In general I can say that it has a stronger effect on social anxiety, although I would not call me a typical socialphobic. I dont have any physical signs of anxiety, and just general dont feel comfortable when there aur many people around me and dont talk want to much (and havent had any girlfreind the last 8 years :-( because of depression, anxiety. and no, I am not just ugly :-) ). Lyrica improved it from day 1 on, but the effect seems to wear off within some days, but a noticeable improvement still exists.
1 Week before starting Lyrica I added T3 thyroid hormone agumentation to my regimen, which also really improves my condition, especially cognition and concentration.
One month after that I added "Nicergoline" (an ergot alkaloid), a vasoactive drug, which also increases catecholamine turnover, especially dopamine and blocks alpha adrenergic activity to some extend, increases protein synthesis inside the cells, increases glucose utilisation, oxygen concentration, increases vigilance etc. etc. It serves as a mild *psychostimulant* without causing depression or crash! Its really a great drug so far, for me... ! Also a a scavenger of free radicals etc. etc. Search at www.pubmed.org for details. This drug really does a *lot* in the body.
And the second big hit for me is "Pentoxifylline". Also a vasoactive drug (available in the US under the brand name "trental"). monograph : http://www.rxlist.com/cgi/generic/pentox_cp.htm
Its a little bit sedating, so I take it at night. Adding this drug to my cocktail further improves my mental status. Also this drug does quite a lot. search at pubmed if interested. It has immuno modulatory properties for example, has an antiinflammatory effect, etc. etc.
Again, the experience is limited, because by now, the T3 augmentation should really "kick" in, according to my doc, which takes about a month or so.
Anyway, after adding Nicergoline and Pentoxifylline my condition really improved very much! I also believe this is because of more blood, and so also more drug molecules reach the right spot, the brain. **They are very powerfull AD augmentors for me!** Increasing mental energy, concentration ,mood and also further reduce social anxiety.... I am fully satisfied with my drug treatment right at the moment. Now its time to do some therapy to restore my destroyed life....So if you suffer from cognitive impairment, which is unresponsive to the common drugs like Adrafinil, Ritalin, Aniracetam, piracetam, Reminyl, Exelon etc. (which all make me *worse*), you should give the vasoactive drugs a go. And I am "just" 25 years old.. I am glad I could convince my current doc to give these drugs a go, because he agreed that I might be after a "side effect" from some drugs. Amitriptyline for example is also a powerful vasodilator via multiple mechanisms... Many drugs also alter cerebral blood flow to some extend.... Most anticholinergis relax smooth muscle cells, which are also "wrapped" around the blood vessels, as far as I know.
I am getting better week by week.... yay!! The extra blood in my head feeds my brain cells with nutritients, monamine precursors etc.. yummy :-)So now I take a load of tabs a day..
nortriptyline 150mg
amisulpride 50mg
Lyrica 450mg (150mg three times a day)
Clonazepam 0,375mg (want to get rid of this)
T3 25ug
Nicergoline 30mg
Pentoxifylline XR 600mg
Diphenhydramine 100mgAnd 3 cups of coffee a day is also part of my coctail. Its essential, also like Smoking. I tried to stop by using a nicotine inhaler, but nada, only attenuates nicotine craving and does nothing for my mood etc... guess its the MAO-B inhibitor in the tobaco smoke..
And I hoping that this positive trend continues...
wich me luck people :-)
'nuff said
Roland
poster:rod
thread:434128
URL: http://www.dr-bob.org/babble/20041223/msgs/434128.html