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Re: Cortisol synthesis inhibitors-NEWS for depress

Posted by Dave001 on December 24, 2004, at 16:48:35

In reply to Re: Cortisol synthesis inhibitors-NEWS for depression, posted by SLS on December 24, 2004, at 10:00:08

> Hi Jerry.
>
> Thanks to supplying the link for the article.
>
> Check this out:
>
> http://www.patient.co.uk/showdoc/30003048/
>
> It appears that metyrapone is available in England for the treatment of various conditions. You can do the rest of the math. :-)
>

Adrenal steroid inhibitors have been around for a long time. Aminoglutethimide (Cytadren in the U.S.) is one such example that's cheap and easily available. Adrenal steroid production is blocked by inhibiting the enzyme desmolase. Aminoglutethimide blocks aromatase as well, an enzyme responsible for the conversion of testosterone to estrogen.

I don't see why anyone would want to mess around with systemic cortisol levels unless they have Cushing's Syndrome or some other condition causing pathophysiologically high cortisol levels. Either that or a death wish. I would be very careful.

Dave


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poster:Dave001 thread:433457
URL: http://www.dr-bob.org/babble/20041223/msgs/433842.html