Posted by paulbwell on December 23, 2004, at 9:08:38
In reply to Take L-phenylalanine or DLPA each morning, posted by 3 Beer Effect on December 21, 2004, at 20:59:29
> >I believe one of the reasons for tolerance is that there is not enough dopamine stored in the synaptic cleft to be released in consecutive doses because your body makes dopamine from l-phenylalanine which is converted to l-tyrosine & then to dopamine. Taking l-phenylalanine daily is supposed to increase dopamine production & theoretically should reduce both tolerance & post-amphetamine withdrawl/depression (crash). You could take l-tyrosine which is one step closer to dopamine but I donīt like l-tyrosine because it does not cross the blood brain barrier while l-phenylalanine does. Even better may be DLPA (dl) phenylalanine because the d-phenylalanine is converted to PEA (Phenythylamine) which drugs like Ritalin & Amphetamine increase markedly in the brain. I would also take a multivitamin with a tall glass of milk before bed each night, but only take the vitamin at night, because multivitamins are acidic & anything acidic reduces effectiveness of amphetamines. But B12, Folate, & B6 are probably very important to turn phenylalanine into dopamine. I found that for maximum effectiveness amphetamines are best taken with either water or skim milk on an empty stomach. But not eating causes the problem of not being able to produce dopamine because the amount of dopamine produced depends on the amount of proteins you take in & no food = not enough protein = not enough dopamine to be released = tolerance.
>
> But if you take amphetamines exactly as prescribed, ie once in the morning or at most twice daily & you take your phenylalaine every morning, there should be little to no tolerance & a several months to a year down the road you should be sensitized to it meaning that just swallowing the pill in the moring causes a weird reaction where you feel the dopamine release / effects of the amphetamine even before it is possible that the pill has made it to your brain. And supposedly the effects will increase slightly over time, although I always abused my Dextrostat in 3 day binges so I never got to the point of use as directed for more than a month at a time.
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> Theoretically, an alpha-2 antagonist like Remeron (mirtzapine) will accelerate the effectiveness of amphetamines through norepinephrine disinhibition but I have never tested this theory myself & the antihistamine effects could possibly counteract amphetamine.
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> Also, I suspect that selegeline/eldepryl/l-deprenyl at 5 or 10 mg per day would increase the subjective effects of amphetamines but I have never tried this because I would be worried about the possibility of a hypertensive crisis, although I suspect that you might be okay with an amphetamine like Dextrostat that has less effect on blood pressure but maximal CNS stimulation than with a mixed dl amphetamine like Adderall which has a tendency to raise your blood pressure more. But it is possible that a hypertensive crisis is more likely with psuedoephedrine or ephedrine because of their much stronger actions on blood pressure.
> Has anyone here combined Selegeline with an amphetamine?
>
> Thanks & be careful because prescription adhd amphetamines are a powerful drug that can really bite you in the a**, in sufficient doses (40-80 mg up the nose, 80 mg or more = cops are looking in my window schizo paranoia! ) they are as very similar to an in sufficient doses are as powerful as street meth (dextostat, adderall) or coke (ritalin especially the pure 20 mg pills or 10 mg focalin pills when snorted is very close to cocaine except it doesnīt numb your nose) & can cause a downward spiral of addiction, paranoia, & anorexia. (I canīt believe they give this stuff to kids!) I havenīt taken Dextrostat in about 3 years but every morning I wake up for work I have an intense craving for it, the only cure iīve found for amphetamine craving is 100 mg of caffeine (1/2 a no-doz) + 20 mg generic prozac + 5 mg selegeline.
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> Cheers,
> 3 Beer Effect
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> Hi,Great to see u back 3 Beer, missed your excellent knowledge,
Does anyone have an answer for preventing methylphenidate tolersnce???
All the anti-tolerance choices seem to relate to the AMPS.
Cheers
> >
> > Has anyone found any successful ways to reduce amphetamine tolerance? eg. memantine etc.
> >
> > Ed.
>
>
poster:paulbwell
thread:432570
URL: http://www.dr-bob.org/babble/20041223/msgs/433280.html