Posted by TomG on December 11, 2004, at 21:07:20
In reply to Re: To Tom, posted by ed_uk on December 11, 2004, at 19:31:07
Well Ed, my doctor always asks me when we start talking about this sort of thing, "Why does it matter?". I agree with him that trying to guess what mechanism the sedation is caused by is sort of useless. I do know that my sedation didn't start until about two months into taking Geodon. I experienced *no* sedation during the first two months except a little each night after I would take it. I also tried Provigil and it had absolutely no effect on the sleepiness whatsoever. So, you may be right the sedation may be caused by 5ht2a antagonism, but theres not a whole lot I can do about that. I may be benefitting from the 5ht2a antagonism that Geodon provides. Most of the newer atypicals provide 5ht2a antagonism and some of the older ones do as well. At this point I know I need an antipsychotic and the only thing there is left to do is to try them all. Hopefully I can find one just as good as Geodon without the sedation.
poster:TomG
thread:427750
URL: http://www.dr-bob.org/babble/20041211/msgs/427983.html