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Nabilone for anxiety

Posted by ed_uk on December 4, 2004, at 17:26:00

Hi,

Nabilone is a synthetic cannabinoid which has been available in the UK for many years. It is an antiemetic. Since the development of newer antiemetics such as ondansetron, nabilone is rarely used.

Has anyone ever been prescribed nabilone for anxiety? Did it have any effect?

J Clin Pharmacol. 1981 Aug-Sep;21(8-9 Suppl):377S-382S. Related Articles, Links

The efficacy and safety of nabilone (a synthetic cannabinoid) in the treatment of anxiety.

Fabre LF, McLendon D.

The anxiolytic properties of nabilone, a synthetic cannabinoid resembling the natural cannabinoids, were studied in 25 outpatients suffering from anxiety. The drug was compared with a placebo in a double-blind manner over a 28-day treatment period. Patients were seen weekly by the physician and were rated by the Hamilton Rating Scale for Anxiety and the Patient's Global Evaluation as well as by patient-rated evaluations. The results of the study showed a dramatic improvement in anxiety in the nabilone group when compared with placebo (P less than 0.001). Side effects reported were dry mouth, dry eyes, and drowsiness. Patients did not report any of the subjective "altered state" experience of marihuana.


Ed.


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