Posted by ed_uk on November 30, 2004, at 9:24:57
In reply to drug-induced illness, posted by lostforwards on November 30, 2004, at 8:25:33
The antipsychiatry site which stated that the use of APs can lead to the development of personality disorders may have been refering to 'tardive dysmentia'.........'The typical apathetic state of tardive dyskinesia patients may be punctuated by periods of hyperactivity, vigilance, and tension. Patients may exhibit unusual readiness for contact, even though they remain edgy, loud and loquacious, euphoric, jolly, intrusive, and invasive of the privacy of others. These features designated as "tardive dysmentia" are examined, so as to draw attention to the possibility that the syndrome of dysmentia is comprised of occasional excessive emotional reactivity, enhanced responsiveness to environmental stimuli, and indifference to or reduced awareness of the patient's abnormal involuntary movements.'
It is interesting to note that symptoms suggestive of 'supersensitivity psychosis' have been reported in people with no history of psychosis. Here is an interesting report...... (metoclopramide is an anti-emetic drug which acts as a dopamine antagonist).Metoclopramide-induced supersensitivity psychosis.
Lu ML, Pan JJ, Teng HW, Su KP, Shen WW.
Department of Psychiatry, Taipei Medical University--Wan Fang Hospital and Taipei Medical University, Taipei, Taiwan.
OBJECTIVE: To report 2 cases of metoclopramide-induced supersensitivity psychosis. CASE SUMMARIES: A 74-year-old Taiwanese man was treated with metoclopramide 5 mg 4 times daily for 6 months. A second patient, a 65-year-old Taiwanese man, was treated with metoclopramide 5 mg 4 times daily for 3 months. After discontinuation of metoclopramide, both patients developed hallucinatory experiences and delusions. DISCUSSION: This is the first report of metoclopramide-induced supersensitivity psychosis. Chronic administration of a dopamine antagonist (e.g., metoclopramide) might induce dopamine receptor supersensitivity. It is hypothesized that exacerbation or occurrence of psychotic symptoms following neuroleptic withdrawal results from mesolimbic dopamine supersensitivity. CONCLUSIONS: The complications of long-term metoclopramide therapy should be seriously considered when the treatment regimens are being planned. Clinicians should attempt to treat patients with the lowest effective dosage of medication for the briefest therapeutic period to minimize the risks of adverse reactions.
Ed.
poster:ed_uk
thread:422246
URL: http://www.dr-bob.org/babble/20041128/msgs/422273.html