Posted by KaraS on November 25, 2004, at 1:58:17
In reply to Re: Good news: Dov's ocinaplon in phase III, posted by pseudonym on November 24, 2004, at 16:25:20
> You are cetainly correct regarding the promotion of Buspar. Yet never, in any test I have heard or read, was Buspar shown it be as effective an anxiolytic as Valium. The same goes for the SSRIs, now that I think of it. Ocinaplon is consistently shown to be more effective an anxiolytic than Valium at doses which do not induce sedation, muscle incoordination, and amnesia. Also, there is a completely different mechanism of action between buspar and ocinaplon. Ocinaplon targets the GABA-A receptor subtypes which are anxiolytic, and does not target those which are responsible for sedation and amnesia. You can think of ocinaplon as benzo- (benzo minus), in that it targets the GABA-A "anxiety receptors", not each and every GABA-A receptor, like all current benzos.
Thanks for explaining that. This certainly does sound like an exciting new drug. I sure hope it's as good as its sounds.
poster:KaraS
thread:419216
URL: http://www.dr-bob.org/babble/20041123/msgs/420016.html