Posted by Larry Hoover on November 23, 2004, at 12:30:09
In reply to serotonin syndrome question, posted by mesonage on November 22, 2004, at 23:41:59
> Hi all,
>
> I was just wondering about the possibility of serotonin syndrome from combining an SSRI with narcotic painkillers (Lexapro and hydrocodone). I remember seeing something a while back of a case of either Serzone or Paxil with Vicodin - since Serzone, Paxil and Lexapro are all SSRI's, do you think it's a valid concern? My doc says no, but I think he downplays many of my concerns. Also, as Lexapro is fairly new, there may not be as much info, so I guess I'm just asking for guesses. What do you guys think?I think you're confusing risk with probability. There is a risk that someone taking Lexapro, for example, all by itself, will develop serotonin syndrome. It happens, but it's very rare.
Taking hydrocodone with Lexapro might increase the risk of serotonin syndrome, but it will still be a very rare consequence. There is no warning in the drug monograph of Lexapro (or Celexa) about the combination. The two drugs are metabolized by different liver enzymes, as well.
Serotonin syndrome doesn't kill anyone quickly. It kills only when it is severe, and when it's not treated. Most cases are mild, and self-limiting (they go away on their own when the offending medication is discontinued). What would be best is for you to familiarize yourself with the symptoms, and go see a doctor right away, if they happen to you.
http://www.mindbodyconsult.com/protocols/serotonin.html
Lar
poster:Larry Hoover
thread:419171
URL: http://www.dr-bob.org/babble/20041123/msgs/419338.html