Posted by Ktemene on November 22, 2004, at 7:59:34
In reply to Re: still doing well on selegiline?? » Ktemene, posted by KaraS on November 19, 2004, at 20:01:45
> Ktemene,
>
> What a pleasant surprise to see your name back on the board. How are you? Are you still taking selegiline and is it still effective for you?
>
> I tried it a couple of times with DLPA but it put me to sleep so I stopped it. Long story but I am getting ready to try it again.
>
> Kara
>
Hi Kara,Thanks for asking about me. I am still taking 5mg Selegiline per day. This is month 4 on Selegiline for me. My doctor has prescribed Selegiline Hydrochloride capsules, and after breakfast I open the capsules and take the powder and hold it under my tongue for a few minutes. I also take either DLPA or L-PA, usually 500 or 1000mg in the morning before breakfast, and I then do aerobic exercise for 40 or 50 minutes. I read that exercise increases PEA in the brain (http://bjsm.bmjjournals.com/cgi/content/full/35/5/342) and so I am hoping to increase PEA, and in any case exercise is helpful for depression.
Selegiline has worked better for my long-term atypical depression (lots of fatigue and somnolence) than any other mediation, and I have tried many. I still have problems with insomnia, and I have tried several different benzos and Remeron to deal with that. The problems with the benzos and Remeron is that they all make me feel tired in the daytime, but that feels like depression to me. Now I am trying melatonin, which seems to work as well and perhaps better than anything else for insomnia. Apparently melatonin also has neuroprotective properties, and I suspect that part of Selegiline's effectiveness for some of us is that it is neuroprotective.
I am going through a stressful period at work, and so I am not doing as well as I was 10 weeks ago, but I think I dealing with the stress better than I would without Selegiline.
I noticed that Larry has been trying Selegiline and had some problems with acid reflux. I did not realize that acid reflux could get that bad, and it is a shame that it is happening with a medication that might be helpful to him.
It is unusual that Selegiline + DLPA put you to sleep. Have you thought about trying L-PA instead DLPA? Some one, I think it was Elleff, suggested that d-phenylalanine might be sedating because of its inhibiting effect on enkephalinase.
Ktemene
poster:Ktemene
thread:417964
URL: http://www.dr-bob.org/babble/20041118/msgs/418887.html