Posted by Franz on November 21, 2004, at 23:03:11
Hello,
I have read good reports about tieneptine (Stablon) but I also read the liver does not process it by the P450 cytochrome but by beta oxidation at the mitochondria.
Pharmacol Ther. 1995;67(1):101-54.
Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity.Fromenty B, Pessayre D.
Institut National de la Sante et de la Recherche Medicale Unite 24, Hopital Beaujon, Clichy, France.
Severe and prolonged impairment of mitochondrial beta-oxidation leads to microvesicular steatosis, and, in severe forms, to liver failure, coma and death. Impairment of mitochondrial beta-oxidation may be either genetic or acquired, and different causes may add their effects to inhibit beta-oxidation severely and trigger the syndrome. Drugs and some endogenous compounds can sequester coenzyme A and/or inhibit mitochondrial beta-oxidation enzymes (aspirin, valproic acid, tetracyclines, several 2-arylpropionate anti-inflammatory drugs, amineptine and tianeptine); they may inhibit both mitochondrial beta-oxidation and oxidative phosphorylation (endogenous bile acids, amiodarone, perhexiline and diethylaminoethoxyhexestrol), or they may impair mitochondrial DNA transcription (interferon-alpha), or decrease mitochondrial DNA replication (dideoxynucleoside analogues), while other compounds (ethanol, female sex hormones) act through a combination of different mechanisms. Any investigational molecule should be screened for such effects.
How safe is tianeptine and what are the risks?. I do not understand if the liver problems it can cause are reversible or not. Should we wait until it is more researched?Anyone here had any problems with it?.
Thanks.
poster:Franz
thread:418797
URL: http://www.dr-bob.org/babble/20041118/msgs/418797.html