Posted by ed_uk on November 21, 2004, at 7:28:21
In reply to Lofepramine is a pro-drug, but not inert » SLS, posted by Jonathan on November 21, 2004, at 6:05:44
Hi Jonathan,
Thank you for the excellent information.
You're right about desipramine being withdrawn, it wasn't very popular. GPs here prescribe dothiepin nearly as much as fluoxetine!
Do you live in the UK? Have you ever taken lofepramine?
Lofepramine is very popular among psychiatrists because of the low risk of overdose compared with other TCAs. Pdocs here tend to use amitrip for sleep rather than depression.
From Lundbeck Psychotropics....'Lofepramine.....Extensive first-pass metabolism to desipramine. Mean plasma half-life approx. 5 hours. Main metabolite is desipramine. Withdrawn in may countries.'
Basically, I would like to know why lofepramine was withdrawn in some countries. Was it just because it wasn't very popular? There have been rare reports of hepatotoxicity with lofep, I wondered whether this was responsible.
A message to everyone...
Was lofepramine withdrawn in your country? Do you know why?All the best...
Ed
poster:ed_uk
thread:418430
URL: http://www.dr-bob.org/babble/20041118/msgs/418552.html