Posted by jujube on November 16, 2004, at 8:37:21
In reply to Clomipramine and a beta blocker?, posted by Keith Talent on November 16, 2004, at 7:03:38
Keith,
I was prescribed a TCA (actually Clomipramine) a couple of weeks ago. At that time I did some research and found information on TCA interactions and what the interaction would result in. The charts indicated that TCA interaction with Beta Blockers such as Propranolol results in the TCA possibly causing greater than expected drops in blood pressure (could explain your fainting/nausea/weakness episode after the gym.
Anyways, there is a whole list of other interactions and what the results could be. Here is the webpage if you want to have a look.
www.holisticonline.com/Remedies/Depression/dep_interactions-TCA.htm
Tamara
> I experienced a nasty fainting/nausea/weakness episode after coming out of the gym. My heart was racing and I'm just wondering if it's dangerous to take both classes of drugs simulataneously. They both reduce inotropic state (to the point of high-output heart failure?). Clomipramine has a prodysrhythmic effect, and my heart was missing beats during the incident.
>
> Busyness/procrastination have prevented me from exercising regularly, so there was a sudden large demand placed on the heart. My dilemna is that both my psychiatrist and me are going away within days.
>
> Should we: ditch the cloimipramine for an SSRI
> ditch the beta blocker (and use the TCA to reduce myocardial contractility)
> ?
> I am on other antihypertensive agents (hydrochlorothiazide, irbesartan, lercanidipine).
>
> Any advice would be appreciated.
>
poster:jujube
thread:416569
URL: http://www.dr-bob.org/babble/20041113/msgs/416612.html