Posted by SLS on November 12, 2004, at 7:56:07
In reply to Re: What do you think of Parnate + amisulpride? » SLS, posted by Chairman_MAO on November 11, 2004, at 12:59:40
Hi CM.
> Have you considered trying parnate + amisulpride?
Not really, although it's a good thought. In the past, I have tried adding Risperdal and Zyprexa to a combination of Parnate + desipramine. My reactions were the same. I experienced a significant (25% improvement) antidepressant within the first few days that lasted for 5 days or so.
> Or Parnate + amisulpride + memantine/lamictal/other NMDA antagonist?
If I do try adding amisulpride, I will definitely be taking Lamictal 300mg.
> I've also been wondering about whether amisulpride would prevent DA agonists from eventually causing lethargy by preventing them from stimulating the autoreceptors.
Isn't that something how consistently Mirapex produces a latent lethargy? I guess something is happening presynaptically, as this phenomenon looks similar to low-dose apomorphine-induced sedation. I think the success of your strategy would depend upon the relative affinities of the two drugs for the receptor. Amisulpride is an extremely potent ligand for the presynaptic receptor, much more so than sulpiride. I don't know how it compares to the various agonists, though. One would like amisulpride to be a stronger ligand than the agonist. The following values that I found on the Internet represent the affinity of ligand for the D2 receptor. However, it doesn't diffentiate between presynaptic versus postsynaptic affinities. Presynaptic receptors are of substantially higher binding affinity than postsynaptic. If we assume that the ligands bind to both pre- and post- synaptic receptors in the same relative order of affinity, then your strategy might work.
K(i) for D2
amisulpride 1.3 - 3.8 nM
pramepexole 750 - 1500 nM
ropinerole 650 - 1000 nMI appreciate your input.
- Scott
poster:SLS
thread:413243
URL: http://www.dr-bob.org/babble/20041108/msgs/414931.html