Posted by ed_uk on November 9, 2004, at 6:45:20
In reply to Re: The Forbidden Combination, posted by ed_uk on November 9, 2004, at 6:11:22
The manufacturer of reboxetine, a selective norepinephrine reuptake inhibitor, claims that it should not be combined with an MAOI. They say this despite the fact that there doesn't appear to be any scientific evidence to support the existence of an interaction. Their warning seems to be based purely on the fact that serious interactions have been reported between MAOIs and other antidepressants.
Has anyone ever been treated with a combination of an MAOI plus desipramine, reboxetine or lofepramine? Was is helpful? Did an interaction occur? I know Scott has tried it- there must be someone else who has!
Nortriptyline is somewhat less selective as a NRI. Serotonin syndrome is possible with Nort+MAOI. Has anyone found this combination useful?
Ed.
PS. I just found a reference to an article which apparantly reports a serious interaction between phenelzine(Nardil) and desipramine. Here it is...
Bowen LW. Fatal hyperpyrexia with antidepressant drugs. BMJ (1964) 2, 1465.
I will find the journal in the library shortly. I will post what I find.
poster:ed_uk
thread:413243
URL: http://www.dr-bob.org/babble/20041108/msgs/413699.html