Posted by ed_uk on November 8, 2004, at 12:13:33
In reply to Re: The Forbidden Combination, posted by Squiggles on November 8, 2004, at 11:21:34
*A warning to everyone who has read my post*
Please read my post carefully, at *no* point did I suggest that anyone should consider taking a combination of a serotonin reuptake inhibitor and an MAOI in the future. This combination can be fatal. (See reference 1 below.) I was asking whether anyone has been treated with this combination in the past. Some people may have received this combination inadvertently eg. if an MAOI was started soon after stopping fluoxetine (Prozac)-an SSRI which is notable for its long half life.
It is very important to bear in mind that there are *no* clinical trials which support the efficacy of combining an SSRI with an MAOI, I was asking to hear people's personal experiences of this combination.
REF 1. Numerous fatalities have been reported due to SRI-MAOI interactions. The TCA clomipramine is an example of a drug which inhibits the re-uptake of serotonin. Tranylcypromine is an MAOI which is sold under the brand name Parnate. Here is a summary of the interaction...
Anaesthesia. 1987 Jul;42(7):760-3. Related Articles, Links
Fatal disseminated intravascular coagulation following a monoamine oxidase inhibitor/tricyclic interaction.Tackley RM, Tregaskis B.
In spite of intensive therapy, an otherwise fit 34-year-old man died following the hyperpyrexial reaction to an interaction between tranylcypromine and clomipramine. There was no evidence of drug overdose, but severe disseminated intravascular coagulation developed which proved fatal.
....The hyperpyrexial reaction was almost certainly what we now know to be the serotonin syndrome.
poster:ed_uk
thread:413243
URL: http://www.dr-bob.org/babble/20041108/msgs/413299.html