Posted by Ritch on November 5, 2004, at 13:08:38
In reply to Seroquel PRN?, posted by Wildman on November 3, 2004, at 19:42:32
>I find that sometimes I benefit from 12.5mg of Seroquel in the afternoon if I am all wound up. I find that it really helps me to settle down and keeps me from wandering around during work.
Seroquel has a short half-life. It's dopamine receptor blocking ability is reduced by more than half after about 12 hrs (from what I read somewhere about a radiolabeled PET scan study). Whenever I was taking a tiny dose (25mg) at bedtime for sleep I had a zingy "bounce-back" syndrome of intense stimulation (felt like amphetamines) about 16-24hrs post-dosing. Taking a tiny dose midday is probably a good solution.
poster:Ritch
thread:411301
URL: http://www.dr-bob.org/babble/20041103/msgs/412185.html