Posted by jboud24 on November 2, 2004, at 20:17:50
In reply to Re: I need a new pdoc and I need some SLEEP!, posted by King Vultan on November 2, 2004, at 18:46:49
My pdoc also taked about Sonata and Ambien with me today at my appt. He said that they work on the sub-type of the BZD receptor complex that mediates sedation. There are two components: one for sedation/hypnosis and another binding site on the oppossing sub-unit that is resposible for anxiolysis. He said that benzos have different preferences as to where they bind to, like xanax binds with a much higher ratio to the anxiolytic sub-unit, Klonopin binds to both non-preferentially, and Ambien and Sonata bind to the sedatitive sub-unit with a ratio of 13:1.
Basically I thought this was important since by not binding to the anxiolytic sub-unit, Ambien and Sonata do not have addictive qualities and do not interfere with the ability (of someone who is concurrently taking benzodiazepines) of a benzo to still keep giving its anxiolytic benefits.Just thought I'd post what my doc and I discussed today since I thought it may be relevant.
Justin
poster:jboud24
thread:410701
URL: http://www.dr-bob.org/babble/20041029/msgs/410839.html