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Re: Psychotropics' overview link? » banga

Posted by SLS on November 2, 2004, at 15:03:08

In reply to Re: Psychotropics' overview link?, posted by banga on November 2, 2004, at 10:54:12

> Thanks again, great informative links! Good to have them all in one place! I commend your work, Scott.

Tanx.

> One question: do we simply not know more specifically about Cymbalta's action--which specific NT sites are affected?

I'm not sure. Reuptake inhibition is presumed by many to be global and without localization. I'm not so sure about that, though. I think there may be regional differences at which these drugs exert their effects.

> I'm still unsure why it is theorized to also have antianxiety effects...

I think most serotonergic drugs have antianxiety properties. Cymbalta is pretty potently serotonergic, despite a more appreciable effect on NE relative to Effexor. I'll tell you what, though. If the reports here are reflective of the general population, Cymbalta might have greater anti-anxiety properties than the others.

> And-do Pamelor and Adrafanil possibly cancel out on NE alpha effects (antagonist vs agonist, respectively)?

No, they do not cancel each other out. It was determined four years ago that adrafinil and modafinil do NOT bind to NE-alpha receptors.


- Scott

 

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URL: http://www.dr-bob.org/babble/20041029/msgs/410693.html