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Re: Nefazadone (Not Covered) Running Out of OptIons

Posted by King Vultan on October 31, 2004, at 23:19:31

In reply to Nefazadone (Not Covered) Running Out of OptIons, posted by Temmie on October 31, 2004, at 20:33:03

Trazodone is really pretty close to nefazodone. About two thirds of the molecule is identical if you look at them side by side, and I believe the mCPP metabolite is common to both. Trazodone is more sedating, but nefazodone is not without sedative qualities, either. There is no way trazodone would not be covered under your insurance--it might be worth giving it a try unless you already have tried this at some time in the past.

After trazodone, the next closest would be the tricyclics, such as imipramine and nortriptyline. Imipramine would be closer to nefazodone but is much more anticholinergic (dry mouth, constipation, etc.). Nortriptyline is more noradrenergic than nefazodone, but it has relatively mild side effects for a tricyclic and works in a very different manner than do the SSRIs or Effexor. Both imipramine and nortriptyline are moderately sedating, probably less than trazodone, which is considered to be quite sedating.

Todd


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poster:King Vultan thread:409798
URL: http://www.dr-bob.org/babble/20041029/msgs/409864.html