Posted by King Vultan on October 29, 2004, at 7:50:16
In reply to Re: MAOIs and anxiety, confusing! my life an apology, posted by ravenstorm on October 28, 2004, at 23:24:57
>
> Kind of freaked at how harsh the discontinuation is. If I got this screwed up coming off paxil wayyyyy slowly what the heck would happen to me if parnate or nardil didn't work? By the way, how much of a washout do you have to leave between MAOIs?
>The standard washout period switching between the traditional MAOIs is two weeks, which I think is wise. Nardil, in particular, has a very long half life of MAO-A inhibition, despite the fact that the drug itself only has a half life of a few hours. Why Nardil and Parnate differ in their half lives of MAO-A inhibition is something I don't quite understand.
> As far as constipation. I seem to get the opposite (EXCEPT on paxil). But that is from the SSRIs, and maybe that would have passed if I could have gotten through the start ups of celexa and lexapro.
>
> Thanks again for your information. It has helped a lot reading your past posts as you have tried both nardil and parnate. You seem to have responded pretty well to both. (Oh, I can't remember--did you have sexual side effects on nardil?) I've heard some people only respond to one and not the other. Wierd. Sometimes I think this stuff is all chemical voodoo!
>
> Do you think you'll try the patch when it comes out? or are you pretty happy on the parnate?
I seem pretty weak in the dopamine/libido department to begin with, and Nardil lowered my libido even more; although, my understanding is that this is a little unusual and not as common as it is with SSRIs. Nardil also definitely delayed orgasm, which no other drug that I've ever tried was able to do. I must profess to not having much interest in the patch; I would probably be more inclined to try selegiline orally first, but I don't think it will be necessary, given that Parnate seems to be pretty well suited to me.Todd
poster:King Vultan
thread:405309
URL: http://www.dr-bob.org/babble/20041029/msgs/408689.html