Posted by steve12 on October 25, 2004, at 21:30:25
In reply to Re: Xanax and tolerance: studies available?, posted by ed_uk on October 25, 2004, at 9:34:58
All sponsored by the drug companies, right? The truth is that Xanax will always be addictive b/c of its short half-life (which the XR version doesn't solve). That's a fundamental of pharmacology. The real issue is, whether dependence is *justified* given the improvemnt in your symptoms.
> Hi!
> Here is a list of studies posted by Elizabeth in 2001, you can find the abstracts on pubmed and print them out to show your pdoc....
>
> J Clin Psychopharmacol 1998 Dec;18(6 Suppl 2):12S-18S. Panic disorder: long-term pharmacotherapy and discontinuation. Rickels K, Schweizer E.
>
> Neuropsychopharmacology 1995 Apr;12(2):147-57. Benzodiazepine sensitivity in panic disorder: effects of chronic alprazolam treatment. Cowley DS, Roy-Byrne PP, Radant A, Ritchie JC, Greenblatt DJ, Nemeroff CB, Hommer DW.
>
> Arch Gen Psychiatry 1993 Jan;50(1):51-60. Maintenance drug treatment of panic disorder. I. Results of a prospective, placebo-controlled comparison of alprazolam and imipramine. Schweizer E, Rickels K, Weiss S, Zavodnick S.
>
> Int Clin Psychopharmacol 1993 Summer;8(2):115-8. Three-year follow-up of patients with panic disorder after short-term treatment with alprazolam and imipramine. Lepola UM, Rimon RH, Riekkinen PJ.
>
> J Psychiatr Res 1993;27 Suppl 1:127-42. Maintenance drug therapy of panic disorder. Curtis GC, Massana J, Udina C, Ayuso JL, Cassano GB, Perugi G.
>
> J Clin Psychopharmacol 1992 Oct;12(5):352-4. Discontinuation of alprazolam after long-term treatment of panic-related disorders. DuPont RL, Swinson RP, Ballenger JC, Burrows GD, Noyes R, Rubin RT, Rifkin A, Pecknold JC.
>
> Arch Gen Psychiatry 1989 Nov;46(11):993-9. Clinical and medication outcome after short-term alprazolam and behavioral group treatment in panic disorder. 2.5 year naturalistic follow-up study. Nagy LM, Krystal JH, Woods SW, Charney DS.
>
> Acta Psychiatr Scand Suppl 1987;335:39-46. Pharmacology of the benzodiazepines; with special emphasis on alprazolam. Soderpalm B.
>
> Hope this helps.......
> Ed
>
poster:steve12
thread:406888
URL: http://www.dr-bob.org/babble/20041024/msgs/407215.html