Posted by karaS on October 17, 2004, at 18:08:53
In reply to propityline- a new AD? » karaS, posted by zeugma on October 17, 2004, at 11:59:14
Ok, so you're skipping my long response and only answering my corrections here? You just couldn't wait to make fun of me, could you? :-)
> > I'm having a rare moment of clarity and wanted to make some changes to my last couple of posts in this thread.
> >
> > - First of all, I confused anticholinergic with antithistaminic when discussing cholinergic urticaria.
>
> O.K. But thanks for making me break out my dictionary :)Well, considering how many times you've made me do that, I feel that payback is warranted.
> >
> > - I forgot that Amisulpride was an AP.
> >
> Did you? I didn't notice any confusion on your part.Yes, when I said that I wanted to try that but then later said I was afraid of Abilify and the APs in general.
> > - Thanks for recognizing that I meant protriptyline when I typed propityline.
> >
> "Propityline" might make me more self-pitying. But I would REALLY pity myself if I even noticed that's what you typed :)That's funny because when I saw it later, I read it that way too: "pro-pity-line" Actually I think this one is a better name for an AD.
> > - After looking at Scott's chart, I can see now why you compared Cymbalta with imipramine. I hadn't realized earlier that imipramine has significant 5-HT reuptake inhibition as well.
> >
> Yes, but it's an open question as to whether Cymbalta will actually turn out to be useful in conditions that imipramine isn't. I wonder, since the tachycardia you experienced on NOR was like the tachycardia on DMI, which latter doesn't have much in the way of anticholinergic properties, if the speeded heart wasn't due to what Stahl calls 'pseudo-anticholinergic' properties, i.e. indirect anticholinergic effects mediated by NE potentiation. I think you mentioned that Effexor IR gave you tachycardia, but not XR. Did you go high enough on Effexor XR to get a significant noradrenergic effect?
>
> -zDoes DMI stand for desipramine? I got up to 225 mg of Effexor XR. That's about when the NE starts to really kick in for Effexor, right? - but I don't know if that was enough NE to judge. Based on my history, I will be very surprised if I am able to tolerate the Cymbalta. I hope I'm wrong. Who knows, maybe some day I'll even try it and find out! :-)
poster:karaS
thread:397388
URL: http://www.dr-bob.org/babble/20041012/msgs/404220.html