Posted by hawkeye on October 8, 2004, at 23:11:28
In reply to Cymbalta @ 2 Weeks, posted by RunawayAmericanDream on October 8, 2004, at 14:32:48
You are probably getting a much larger dose of Cymbalta than you realize.
Wellbutrin is a potent inhibitor of the CYP2D6 enzyme.
According to the PDR for Cymbalta: "Because CYP2D6 is involved in duloxetine [Cymbalta] metabolism, concomitant use of duloxetine with potent inhibitors of CYP2D6 may result in higher concentrations of duloxetine."
In short, if you take Wellbutrin and Cymbalta together you could be getting a MUCH HIGHER dose of Cymbalta than indicated from the specifications for the Cymbalta capsule.
I took the two together for a short period of time but got severe sexual side-effects. I then stopped taking the Wellbutrin and continued with the Cymbalta (40mgs/day) and the side-effects almost went away completely.
poster:hawkeye
thread:400464
URL: http://www.dr-bob.org/babble/20041007/msgs/400627.html