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Mode of action is unknown! » ravenstorm

Posted by Cruz on October 6, 2004, at 10:24:42

In reply to Re: Difference between MAO-A and MAO-B? which drugs?, posted by ravenstorm on October 5, 2004, at 17:18:28

I wish there was an understanding of how psychatrophic meds work, but there is'nt. About 25 years ago I began to doubt the monoaminergic theories. As time has gone by more and more research has added more doubt to these theories. For any of us to state that a certain med's mode of action is by modifying the level of this or that nuerotransmitter is erroneous. I feel many of us have an endocrine disorder. Maybe HPA axis problem or something else abnormal in the endocrine system. It is so frustrating waiting and waiting for some insight into the underlying imbalances of mood disorders. To me I see the monoaminergic theories as being a big detriment to advancement. Thanks for the opportunity to vent.
> Thanks for all the information. I think I understand now. BUT, if Nardil, parnate and marplan are all MAO-a and b and affect the same neurotransmitters, why do they affect people so differently? ie, I hear parnate described as activating and nardil described as good for anxiety. What causes the difference? I would think if parnate also affects serotonin then it would be OK for people with anxiety disorders to take it, but perhaps I am wrong.
>
> Thanks everybody, for taking the time to educate me. RS


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