Posted by zeugma on October 5, 2004, at 20:09:39
In reply to are tyrcyclics better for the frontal cortex, posted by linkadge on October 5, 2004, at 19:30:23
no, i think they would be better for PFC activation as most TCA's block NE reuptake and the NE transporter removes dopamine from the synaptic clefts in the frontal cortex. I think also that enhancing serotonin vs. enhancing norepinephrine or dopamine has drastically different cognitive effects. I think 5HT enhances shifting of attention but disrupts concentration to some extent, while catecholamines have the opposite effect.
-z
poster:zeugma
thread:399358
URL: http://www.dr-bob.org/babble/20041002/msgs/399381.html