Posted by pablo1 on October 4, 2004, at 20:09:44
In reply to Re: wellbutrin and dexedrine, posted by bart on October 3, 2004, at 14:59:55
> last time I looked at any clinical pharmacology of wellbutrin it was shown to have a higher affinity for serotonin and norepinephrine and only a little bit for dopamine. But I've heard so many mixed things you know
My understanding is wellbutrin does nothing for seratonin, mostly norepenephrine & a bit on dopamine. I ran across the following chart though which is very contradictory & perhaps misunderstood. The comments below are from other posters asking questions:
Here is a table with the relative values of blockade of NA, 5HT and DA
the greater the value,
the greater the affinity for blocking the re-uptake site.5HT NA DA
Zoloft sertraline 0.2400 341.0000 0.3800
Ritalin
4.0000Seroxat paroxetine 2.5000 798.0000 0.2000
Wellbutrin buproprion 0.0019 0.0110 0.1900
Effexor venlafaxine 0.0940 11.0000 0.0110
Lexapro citalopram 2.7000 86.0000 0.0036
Deproxin fluoxetine 0.4100 123.0000 0.0280
Edronax, Vestra reboxetine 14.0000 1.7000 0.0087
Where did you get these numbers?
The potency stats I have are from A Primer of Drug Action by Robert M.
Julien, M.D., Ph.D.These numbers do not make any sense to me. (First off, did I get the
right numbers under the right neurotransmitters, the table was a little
messed up on my newsreader??) Second, I assume these neurotransmitter
columns and the values under them are ment to represent inhibition of
reuptake of that neurotransmitter (and not inhibition of one of the many
receptor subtypes for each type of receptor). But what really has me
confused is what the values represent numerically. They are presumably
IC50 values (a measure of drug affinity) given in maybe micromolar
concentrations?? If they are, then the lower the numerical value the
greater affinity the drug has for blocking the reuptake of that
neurotransmitter. Sometimes IC50 values are given in -log units, and when
that happens the larger the number the higher the affinity. But that
doesn't seem to be the case here. I am confused.
poster:pablo1
thread:398301
URL: http://www.dr-bob.org/babble/20041002/msgs/398963.html