Posted by Ilene on September 19, 2004, at 22:55:40
In reply to Anyone know if propranalol hits steady state?, posted by Racer on September 19, 2004, at 22:02:45
Short answer: no, if I'm translating correctly. Long answer, see below, or go to http://www.rxlist.com/cgi/generic/propran_cp.htm
"The biologic half-life is approximately four hours.
There is no simple correlation between dose or plasma level and therapeutic effect, and the dose-sensitivity range as observed in clinical practice is wide. The principal reason for this is that sympathetic tone varies widely between individuals. Since there is no reliable test to estimate sympathetic tone or to determine whether total beta blockade has been achieved, proper dosage requires titration. . .
Studies in normal volunteers have shown that a 90 mg b.i.d. regimen maintains beta blockade at, or above, the minimum for 60 mg t.i.d. dosing for 24 hours even though differences occurred at two time intervals. At 10 to 12 hours after the first dose of the day, t.i.d. dosing gave more beta blockade than b.i.d. dosing; at 20 to 24 hours the trend of the relationship was reversed. These relationships were similar in direction to those observed for plasma propranolol levels. "
poster:Ilene
thread:392778
URL: http://www.dr-bob.org/babble/20040915/msgs/392797.html