Posted by Ame Sans Vie on August 29, 2004, at 8:50:10
In reply to Re: Blood levels for desipramine? » Ame Sans Vie, posted by Larry Hoover on August 29, 2004, at 8:07:55
> The lower bound of therapeutic response to desipramine is 116 ng/ml. The upper bound is not clearly established (i.e. that point at which toxicity effects become significant, vis a vis response).
>
> Do you think you can get tested for desipramine concentration? Way cool, if you can.Hopefully -- I plan on calling my pdoc about it tomorrow.
> > I've been taking 200mg daily for close to three weeks now and possibly experiencing some benefit... at the very least it's given my Adderall more of a punch! No side effects at this dose either, save a very mild orthostatic hypotension that I can easily put up with.
>
> You're a tad impatient. Three weeks is not long enough to judge response. Three months is.lol, not impatient so much as pessimistic. I don't expect this stuff to work out in the long run, and besides, I'm a bit concerned about the cardio effects. My blood pressure's definitely a bit higher than normal.
> Do you have any idea what your 2D6 status is? Extensive metabolizers only sustain desipramine concentrations below 50 ng/ml.
I'm definitely an extensive metabolizer... I dunno, guess I'll have to see how it goes.
~Michael
poster:Ame Sans Vie
thread:383581
URL: http://www.dr-bob.org/babble/20040825/msgs/383600.html