Posted by zeugma on August 27, 2004, at 18:56:20
In reply to Re: Buspar for Social Anxiety ? Any success stories ?! » zeugma, posted by SLS on August 27, 2004, at 12:57:11
> > no, unfortunately it did not... however it does have an antidepressant effect, if it had been marketed as an AD and given an extended-release formulation it might have made a good one.
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> Do you think I should put it on my list of things to try as an augmentor. Which antidepressants do you think it works best with?
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> I am dismayed that the FDA dismissed gepirone. I think it would have made an ideal augmentor.
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> - ScottHi Scott. I think buspirone is a reasonable choice as a potential add-on, because it hits a lot of neurotransmitters, and has a very short half-life, so if you have an adverse reaction, it's out of there in a hurry. More substantively, I would guess that it works best with NRI's because of its alpha-2 antagonist metabolite. But the drug is highly variable in pharmacokinetics, so although you're guaranteed to get something (5HT 1A partial agonism, NE autoreceptor antagonism, a little bit of D2 blockade) there's no guarantee that you're going to get what you need (or that you're not going to get something you don't need). The name Variza seemed appropriate for the similar gepirone, except of course gepirone came in an ER formulation that would have resulted in a much higher gepirone/1-PP ratio and would not have affected dopamine directly at all. It would have been a lot more predictable, and effective for more people. I agree that it would have made an ideal augmentor.
-z
poster:zeugma
thread:382642
URL: http://www.dr-bob.org/babble/20040825/msgs/383128.html