Posted by KaraS on August 26, 2004, at 20:04:53
In reply to Adderall tolerance (aka poop-out) revisited, posted by Philidor on August 26, 2004, at 11:12:47
> Sorry to harp on this subject again, but it is important. It recently dawned on me that many posters (me included) have been barking up the wrong tree on this!
>
> All this speculating on neuroreceptors, agonists, dopamine depletion etc., etc., may be missing the point entirely, by focusing on the brain, when the real problem is in the GUT!
>
> How the drug is taken makes a big difference, because there are at least three different ways by which tolerance can develop.
>
> Drugs that are swallowed (like Adderall) may no longer even make it to the brain after a time because the liver thinks they are toxins and starts to release enzymes to neutralize them. Metabolic tolerance. (Check out Question 2):
>
> http://abdellab.sunderland.ac.uk/Lectures/pcl312_exam2004.html
>
> This is just the reason people trying to get high shoot or snort or smoke their stuff instead of swallowing it. To bypass that roadblock.
>
> Phil
That's fascinating to me. I had never heard of that. Gives you hope that if a drug that works for you poops-out, then a patch could make all the difference. Of course there were several other possible reasons for poop-out so it's only one scenario.
poster:KaraS
thread:382536
URL: http://www.dr-bob.org/babble/20040825/msgs/382680.html