Posted by KaraS on August 24, 2004, at 16:29:07
Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity.
Gainetdinov RR, Wetsel WC, Jones SR, Levin ED, Jaber M, Caron MG.
Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
The mechanism by which psychostimulants act as calming agents in humans with attention-deficit hyperactivity disorder (ADHD) or hyperkinetic disorder is currently unknown. Mice lacking the gene encoding the plasma membrane dopamine transporter (DAT) have elevated dopaminergic tone and are hyperactive. This activity was exacerbated by exposure to a novel environment. Additionally, these mice were impaired in spatial cognitive function, and they showed a decrease in locomotion in response to psychostimulants. This paradoxical calming effect of psychostimulants depended on serotonergic neurotransmission. The parallels between the DAT knockout mice and individuals with ADHD suggest that common mechanisms may underlie some of their behaviors and responses to psychostimulants.
PMID: 9888856 [PubMed - indexed for MEDLINE]
Could anyone tell me what that role of serotonin is in this case?
poster:KaraS
thread:381803
URL: http://www.dr-bob.org/babble/20040821/msgs/381803.html