Posted by zeugma on August 20, 2004, at 18:33:17
In reply to Re: New study confirms fears of AD use for kids, posted by linkadge on August 20, 2004, at 16:52:54
I think half-life has a lot to do with it too.. Paxil and Effexor are also the worst offenders in terms of withdrawals, and who knows how quickly a child metabolizes these drugs, given that no one has carried out pharmacokinetic studies in children... they could go through withdrawal and not even know it due to their fast metabolism and that could cause the 'lability.'
Incidentally, noradrenergic AD's don't seem to work until early adulthood. The TCA's have been trialed numerous times in children and didn't separate from placebo, although amitriptyline and imipramine work for childhood enuresis (bedwetting). They also work in childhood ADHD, and seem reasonably safe, except for desipramine, which has caused some cardiac-related fatalities.
poster:zeugma
thread:380024
URL: http://www.dr-bob.org/babble/20040817/msgs/380095.html