Posted by zeebop on August 16, 2004, at 6:31:02
In reply to Re: Non-SSRI Depression relief?, posted by becksA on August 15, 2004, at 23:26:20
> I am reluctant to try MAOI's because of the strict dietary requirements....I would first like to try the Tricyclics you speak of....what are some popular drugs in this class? How do they chemically work differently than SSRI's?
> Thanks
Excellent and famous TCA's :
1- Imipramine (Tofranil) : the oldest and the gold standard AD's : it has equal potency at 5HT/Ne reuptake inhibition : excellent for severe depression,GAD,Panic and ADD
2- Amitriptyline (Elavil/Tryptizoll/Saroten) :
same as above and strong 5HT2 Antagonism ,but much more sedative , so better for insomnia and anxiety and not good for ADD
3- Nortriptyline (pamelor) :
Potent NE inhibitor and 5ht2 Antagonist : also great for severe depression,anxiety,ADD,concentration,but less for anxiety and insomnia
4- Desipramine (Norpramin) :
Also NE inhibitor but weak 5ht2 antagonist : good for depression and ADD,but can cause some anxiety and insomnia
5- Maprotiline (Ludiomil) :
Also a very selective Ne inhibitor with anxiyolitic effects .
6- Clomipramine (Anafranil):
Very potent 5HT inhibitor with some NE inhibition ,so is more like an Effexor - type,and so is the odd one : good for OCD,depression,but sexual side effects and apathy similar to Effex + SSRIsWeight Gain is a problem with all AD's (Except Selegiline,Wellbutrin)...However WG is dose-related with TCA's,while SSRIs are not and continue with time..so much worse in the case of SSRis.
One note : if you don't like all the above,you can try Selegiline which is at 5-10mg is a MAO-B ,so does not have dietry resrictions and affects dopamine ,so is very good for depression,ADD,+ No Weight Gain .
All the best.
poster:zeebop
thread:378077
URL: http://www.dr-bob.org/babble/20040811/msgs/378149.html