Posted by Sad Panda on August 13, 2004, at 3:31:51
In reply to Re: Somebody! I need advice fast! » Sad Panda, posted by Ame Sans Vie on August 12, 2004, at 20:51:02
> > Hi Michael,
> >
> > I like Nort myself & I find it anxiolytic. Desipramine is a potent NE reuptake inhibitor with the least side effects of any TCA. Nortriptyline is also a potent NE reuptake inhibitor, but it's toned down because it adds 5-HT2A antagonism which can be anxiolytic & does improve sleep & counters most SSRI side effects, downside is it does have more A1 & M1 blockade than Desipramine, it also is a modest H1 blocker.
>
> Thanks a bunch for your opinion! So, from what you've said I'm drawing the conclusion that you've tried both desipramine and nortriptyline... could I trouble you to go any deeper into the subjective differences between the two drugs? What *did* each help with?...What *didn't* each help? Sorry, I'm just really wanting to become very knowledge on this subject in case the time comes again that I must weigh nortriptyline as an option.
>
> My pdoc became ill and had to leave the office, so he referred me to a general practitioner friend of his. I figured I'd just go for the desipramine (and *why* I'll explain in a moment <g>) and so she wrote up a script for 180 x 100mg tablets, with one refill, lol (talk about overkill -- thank goodness I haven't experienced suicidal ideation in several years). But hey, if it works well at least I have plenty on hand. About six months plenty to be exact, lol.
>
> ~Why I went with desipramine:
>
> I am constantly coming across the following quote in various places on the web, and it has me intrigued. Maybe I'll be able to cut back on the Adderall? ....
>
> "Amphetamines may enhance the activity of tricyclic or sympathomimetic agents; d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d-amphetamine in the brain; cardiovascular effects can be potentiated."
>
> I had taken 30mg Adderall two hours prior to taking my first two desipramine; the peak of the drug's effect was waning, but within fifteen minutes of taking the desipramine, I felt that nice amphetamine "kick" all over again. I'm *definitely* going to try decreasing my dose of Adderall to 15 or 20mg four times daily starting tomorrow.
>
> ~MichaelHi Michael,
I haven't tried Desipramine. I chose Nort because I need help with sleep & it is the metabolite of Amitriptyline, an AD that has the highest efficacy of all reuptake inhibitors. I believe Zeugma would have the best info on this because he is ADHD like you & is on Nort. Desipramine is the most potent NE reuptake inhibitor with the least side effects, but if you have insomnia and/or anxiety and/or are taking an SSRI, then Nort is probably the better choice.
Cheers,
Panda.
poster:Sad Panda
thread:376819
URL: http://www.dr-bob.org/babble/20040811/msgs/377085.html