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Re: Prozac Wellbutrin??? Is this a good combo?

Posted by King Vultan on August 12, 2004, at 19:52:11

In reply to Prozac Wellbutrin??? Is this a good combo?, posted by woolav on August 12, 2004, at 18:04:31

> In case there are those who dont know what my issues are (i say this because i am always on this site)...I take prozac, lamictal and xanax for panic disorder. What about adding some wellbutrin? Has anyone taken this combo? I would like some sex drive back and I want to be more alert during the day again..
> Thanks!!
> S

A word of caution: both of these drugs are powerful 2D6 inhibitors, and you have the potential for signficant elevations in blood plasma levels of the Prozac, which is a 2D6 substrate. I believe either Wellbutrin or one of its metabolites is also a 2D6 substrate and may also be increased in level. I am aware of at least three reported cases of serotonin syndrome from these two drugs being taken together. I would suggest, at the very least, to avoid high dosages of either when taking them together.

Todd


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poster:King Vultan thread:376972
URL: http://www.dr-bob.org/babble/20040811/msgs/377005.html