Posted by King Vultan on August 11, 2004, at 9:49:30
In reply to Re: Nardil insomnia and restlessness » SLS, posted by Sad Panda on August 11, 2004, at 9:00:04
> > I would be a bit hesitant to recommend doxepin with that high a dosage of Nardil. At 60mg and higher, I think any drug with appreciable serotonin reuptake properties might be problematic.
> >
> >
>
> Hi Scott,
>
> Doxepin isn't really an SRI, you might be thinking of Dothepin. :)
>
> Cheers,
> Panda.
>Doxepin does have some effect on 5-HT reuptake, but it appears to be swamped by its much more powerful H1 blockade, and is probably not a big cause for concern IMO. I agree trimipramine is safer, however, and this is the one I would choose if I had to pick between the two.
The problem I have with using these two tricyclics rather than stuff like Benadryl or hydroxyzine is that the tricyclics have such long half lives in comparison that I think there is a greatly increased chance of being overly sedated the next day. OTOH, these tricyclics have extremely strong histamine blockades and are probably more powerful sleep aids.
Todd
poster:King Vultan
thread:376183
URL: http://www.dr-bob.org/babble/20040811/msgs/376378.html